Product name: PAL-GHK

Synonyms: Palmitoyl Tripeptide-1, C16-GHK

CAS NO.: 147732-56-7

Sequence: Palmitoyl-Gly-His-Lys

M.W: 578.79

M.F.: C₃₀H₅₄N₆O₅

Purity: 98%

Counter ion: Acetate

Grade: Cosmetic/Research Grade

Appearace: Lyophilized powder

Sample order: 1g

Description

Pal-GHK is a hybrid synthetic molecule made of one-part peptide and one-part fatty acid. The “Pal” segment of the name refers to palmitoyl, a well-known fatty acid and common component of mammalian cell membranes. The “GHK” component stands for the peptide sequence glycine-histidine-lysine. This is a small fraction of the much larger elastin protein and a potent stimulant of fibroblasts (cells that synthesize collage, elastin, and other important proteins in the extracellular matrix of skin, bone and other connective tissues). Pal-GHK is often included in research designs with other short peptides.

The self-assembly of three cosmetically active peptide amphiphiles C16-GHK, C16-KT, and C16-KTTKS (C16 denotes a hexadecyl, palmitoyl chain) have been widely used in commercial skin care products. A cream containing 3 ppm palmitoyl tripeptide-1 (palmitoyl-Gly-His-Lys) was applied around the eyes of 15 female subjects twice daily for 4 weeks. Application resulted in a statistically significant anti-wrinkle effect, in that decreased wrinkle length, and depth and a decrease in overall skin roughness were observed. The application of palmitoyl tripeptide-1 (4 ppm in vehicle) to the skin of 23 female subjects for 4 weeks caused a statistically significant increase (4% increase) in skin thickness.

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